Drug Development
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22 hours ago | News
Duke Univ. researchers have devised a method to dry and preserve proteins in a glassified form that seems to retain the molecules' properties as workhorses of biology.
Mar 16 | News
If the price of a new innovation by researchers at Rice Univ. is right, the flat petri dish may soon become an endangered species in the lab. The “invisible scaffold” technique, which relies on gold nanoparticles and engineered phages, builds cultures that more closely resemble native tissue.
Mar 16 | News
The film "Avatar" isn't the only 3-D blockbuster making a splash this winter. A team of scientists from Houston's Texas Medical Center this week unveiled a new technique for growing 3-D cell cultures, a technological leap from the flat petri dish that could save millions of dollars in drug-testing costs.
Mar 10 | News
For decades, the traditional practice in animal testing has been standardization, but a study involving Purdue Univ. has shown that adding as few as two controlled environmental variables to preclinical mice tests can greatly reduce costly false positives, the number of animals needed for testing and the cost of pharmaceutical trials.
Mar 4 | News
Researchers from the Arizona State Univ. have helped advance understanding about the antibacterial activity of clay minerals and their ability to kill what the best antibiotics on the market can't touch.
Feb 8 | News
The finding is limited to mice and rats, but the conclusions of the Columbia Univ. Medical Center study are conclusive: an experimental drug that blocks serotonin synthesis in the gut also blocks the tendency for serotonin to inhibit bone formation. Researchers say the discovery could lead to a new class of drugs.
Feb 2 | News
Any researcher with the Chemical Abstracts Service, which has tens of millions of compounds on file, can tell you immediately: a promising drug compound is a needle in a haystack. At Scripps Research Institute, researchers have combined bead library screening and microarray-based analysis into an automated, efficient system that can test libraries of millions.
Feb 1 | News
Researchers in the UK and the U.S. have together grown a crystal that reveals the structure of an enzyme called integrase, which is found in retroviruses like HIV that use it to paste a copy of its genetic code into infected DNA. New antiretroviral drugs block integrase, but until now scientists didn’t know exactly how they worked.
Jan 22 | News
By combining the tools of medicinal chemistry and zebrafish biology, a team of Vanderbilt investigators has identified compounds that may offer therapeutic leads for bone-related diseases and cancer. The findings support using zebrafish as a novel platform for drug development.
Jan 19 | News
Researchers at MIT and Harvard Medical School have built targeted nanoparticles that can cling to artery walls and slowly release medicine, an advance that potentially provides an alternative to drug-releasing stents in some patients with cardiovascular disease.